TABLE 3.
Associations of ultrasound and radiographic features with primary clinical outcomes
| Baseline a | Change from baseline to 12 week b | |||
|---|---|---|---|---|
| Coefficient (95% CI c ) | P | Coefficient (95% CI c ) | P | |
| Pain | ||||
| Ultrasound‐detected synovitis | 0.42 (−2.61, 3.45) | 0.78 | 3.14 (−2.14, 8.42) | 0.24 |
| Ultrasound‐detected PDS (Yes/No) | −5.16 (−11.02, 0.71) | 0.08 | −6.23 (−16.63, 4.17) | 0.24 |
| Ultrasound‐detected osteophyte | 0.23 (−3.23, 3.69) | 0.90 | 2.47 (−3.57, 8.51) | 0.42 |
| Radiographic JSN | 1.44 (−0.64, 3.51) | 0.17 | 3.41 (−0.22, 7.03) | 0.07 |
| Radiographic osteophytes | −1.22 (−3.57, 1.14) | 0.31 | −0.82 (−4.96, 3.32) | 0.70 |
| Radiographic subchondral bone sclerosis (Yes/No) | −2.62 (−7.15, 1.90) | 0.25 | −4.12 (−12.37, 4.13) | 0.33 |
| FIHOA | ||||
| Ultrasound‐detected synovitis | 0.58 (−0.25, 1.41) | 0.17 | −0.34 (−1.24, 0.55) | 0.45 |
| Ultrasound‐detected PDS (Yes/No) | −0.79 (−2.42, 0.83) | 0.34 | −1.08 (−2.82, 0.65) | 0.22 |
| Ultrasound‐detected osteophyte | 0.82 (−0.13, 1.76) | 0.09 | −0.37 (−1.40, 0.65) | 0.47 |
| Radiographic JSN | 0.90 (0.34, 1.45) | 0.02 | 0.42 (−0.21, 1.05) | 0.19 |
| Radiographic osteophytes | 0.45 (−0.19, 1.10) | 0.17 | 0.31 (−0.39, 1.01) | 0.39 |
| Radiographic subchondral bone sclerosis (Yes/No) | 1.89 (0.67, 3.10) | 0.03 | −0.66 (−2.07, 0.75) | 0.36 |
Abbreviations: CI, confidence interval; FIHOA, Functional Index for Hand Osteoarthritis; JSN, joint space narrowing; PDS, power Doppler signal. The significance of bold values represent positive values (P <0.05).
a
Adjustment for age, sex, body mass index, and duration of disease.
b
Adjustment for age, sex, body mass index, course of disease, and baseline symptoms.
c
95% confidence interval.