TABLE 4.
Association between ultrasound and radiographic features and the secondary clinical outcomes at baseline and changes for 12 weeks
| Baseline a | Change from baseline to 12 week b | |||
|---|---|---|---|---|
| Coefficient (95% CI) | P | Coefficient (95% CI) | P | |
| Grip strength | ||||
| Ultrasound‐detected synovitis | −0.23 (−1.75 to 1.29) | 0.77 | −0.74 (−1.98 to 0.51) | 0.25 |
| Ultrasound‐detected PDS (Yes/No) | 0.88 (−2.08 to 3.85) | 0.56 | 0.49 (−1.95 to 2.93) | 0.69 |
| Ultrasound‐detected osteophyte | −0.14 (−1.87 to 1.59) | 0.87 | 0.94 (−0.48 to 2.36) | 0.19 |
| Radiographic JSN | −0.05 (−1.09 to 1.00) | 0.93 | 0.30 (−0.56 to 1.16) | 0.49 |
| Radiographic osteophytes | −0.99 (−2.16 to 0.18) | 0.10 | −0.41 (−1.39 to 0.57) | 0.41 |
| Radiographic subchondral bone sclerosis (Yes/No) | 0.40 (−1.87 to 2.68) | 0.40 | 1.23 (−0.70 to 3.16) | 0.21 |
| Pinch strength | ||||
| Ultrasound‐detected synovitis | −0.01 (−0.27 to 0.24) | 0.92 | −0.12 (−0.34 to 0.10) | 0.27 |
| Ultrasound‐detected PDS (Yes/No) | 0.07 (−0.42 to 0.57) | 0.77 | −0.05 (−0.48 to 0.37) | 0.81 |
| Ultrasound‐detected osteophyte | −0.05 (−0.34 to 0.24) | 0.72 | 0.01 (−0.24 to 0.26) | 0.94 |
| Radiographic JSN | −0.01 (−0.19 to 0.16) | 0.90 | −0.00 (−0.1 5 to 0.15) | 0.99 |
| Radiographic osteophytes | −0.01 (−0.20 to 0.19) | 0.95 | −0.11 (−0.27 to 0.06) | 0.21 |
| Radiographic subchondral bone sclerosis (Yes/No) | −0.15 (−0.53 to 0.23) | 0.43 | −0.02 (−0.36 to 0.32) | 0.91 |
| Duration of stiffness | ||||
| Ultrasound‐detected synovitis | −0.75 (−5.12 to 3.62) | 0.74 | 0.37 (−5.91to 6.66) | 0.91 |
| Ultrasound‐detected PDS (Yes/No) | −2.61 (−11.13 to 5.92) | 0.55 | −5.57 (−17.82 to 6.68) | 0.37 |
| Ultrasound‐detected osteophyte | −2.93 (−7.90 to 2.03) | 0.25 | 6.14 (−1.00 to 13.28) | 0.09 |
| Radiographic JSN | −0.44 (−3.45 to 2.56) | 0.77 | 5.57 (1.33 to 9.80) | 0.01 |
| Radiographic osteophytes | −1.27 (−4.67 to 2.14) | 0.46 | −0.45 (−5.35 to 4.46) | 0.29 |
| Radiographic subchondral bone sclerosis (Yes/No) | −0.60 (−7.15 to 5.95) | 0.86 | 5.17 (−4.54 to 14.89) | 0.86 |
| PGA | ||||
| Ultrasound‐detected synovitis | 0.11 (−4.89 to 5.12) | 0.96 | 2.29 (−2.31 to 6.89) | 0.33 |
| Ultrasound‐detected PDS (Yes/No) | −9.92 (−19.56 to 0.28) | 0.04 | −2.35 (−11.46 to 6.77) | 0.61 |
| Ultrasound‐detected osteophytes | −0.38 (−6.09 to 5.32) | 0.89 | 3.04 (−2.20 to 8.28) | 0.25 |
| Radiographic JSN | 0.48 (−2.95 to 3.92) | 0.78 | 4.28 (1.18 to 7.38) | 0.01 |
| Radiographic osteophytes | −0.34 (−4.24 to 3.56) | 0.87 | 0.39 (−3.21 to 3.99) | 0.83 |
| Radiographic subchondral bone sclerosis (Yes/No) | −0.23 (−7.73 to7.26) | 0.95 | −0.90 (−8.05 to 6.25) | 0.80 |
| Aqol‐4D | ||||
| Ultrasound‐detected synovitis | −0.59 (−2.51 to 1.33) | 0.54 | 0.86 (−0.53 to 2.25) | 0.22 |
| Ultrasound‐detected PDS (Yes/No) | 1.25 (−2.50 to 4.99) | 0.51 | 0.65 (−2.07 to 3.37) | 0.64 |
| Ultrasound‐detected osteophytes | −1.77 (−3.94 to 0.41) | 0.11 | 0.21 (−1.39 to 1.81) | 0.80 |
| Radiographic JSN | −0.19 (−1.51 to 1.13) | 0.77 | −0.49 (−1.45 to 0.46) | 0.31 |
| Radiographic osteophytes | −0.47 (−1.97 to 1.02) | 0.53 | 0.42 (−0.66 to 1.51) | 0.44 |
| Radiographic subchondral bone sclerosis (Yes/No) | −0.66 (−3.53 to 2.22) | 0.65 | 1.61 (−0.54 to 3.75) | 0.14 |
Abbreviations: AqoL‐4D, Assessment of Quality of Life‐4D instrument; CI, confidence interval; JSN, joint space narrowing; PDS, power Doppler signal; PGA, patient’s global assessment. The significance of bold values represent positive values (P <0.05).
a
Adjustment for age, sex, body mass index and duration of disease.
b
Adjustment for age, sex, body mass index, course of disease and baseline symptoms.