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. 2022 Jul 18;9(4):ENEURO.0120-22.2022. doi: 10.1523/ENEURO.0120-22.2022

Figure 2.

Figure 2.

AVP-elicited inward currents are mediated by depression of Kir channels. A, B, AVP increased the input resistance of DG GCs. A, Voltage responses evoked by the injection of negative currents from 0 to −75 pA at an interval of 25 pA before (left) and during (right) the application of AVP from a DG GC. B, The current–voltage relationship averaged from nine cells. Input resistance was obtained by linear fitting of the current–voltage relationship. C, Currents elicited by a voltage step protocol before (left) and during (middle) bath application of AVP and the net current obtained by subtraction (right) from a GC. Cells were held at −60 mV and stepped from −140 to −40 mV for 400 ms at a voltage interval of 10 mV every 10 s. Steady-state currents were measured within 5 ms before the end of the step voltage protocols. Note the differences in the scale bars. The dashed line was the zero current level. D, I–V curve averaged from 12 GCs before and during the application of AVP. E, I–V curve of the net current obtained by subtracting the currents in control condition from those during the application of AVP. Note that the net currents showed inward rectification, suggesting the involvement of Kir channels.