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. 2022 Jul 6;10:902798. doi: 10.3389/fped.2022.902798

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Copyright © 2022 Rao, Cuna, Chavez-Bueno, Menden, Yu, Ahmed, Srinivasan, Umar and Sampath.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Preterm formula influences the acquisition of the intestinal microbiome. (A) Alpha diversity calculations with Phyloseq software package. Standard diversity metrics were evaluated including observed richness, ACE, Shannon index, and InvSimpson. (B,C) Beta-diversity visualization with Non-metric Multi-dimensional Scaling (NMDS) and Principal Coordinate Analysis (PCoA) plots based on Bray-Curtis distances. (D) The linear discriminant analysis (LDA) value distribution histogram. Taxa meeting a linear discriminant analysis significant threshold > 4 are shown. c: class level; f: family level; g: genus level; o: order level; p: phylum level.