Table 2.

Measure of agreement

Measure of agreement	Results
ICC among pathologists, 22C3	0.834 (CI 0.758–0.896)
ICC among pathologists, SP263	0.868 (CI 0.803–0.918)
ICC between clones	0.911 (CI 0.885–0.931)
Kappa at CPS ≥ 1 between clones	0.891 (CI 0.825–0.957)
OPA at CPS ≥ 1 between clones	98% (CI 95–99%)
PPA at CPS ≥ 1 between clones	98% (CI 95–99%)
NPA at CPS ≥ 1 between clones	97% (CI 85–100%)
Kappa at CPS ≥ 20 between clones	0.808 (CI 0.753–0.862)
OPA at CPS ≥ 20 between clones	90% (CI 87–93%)
PPA at CPS ≥ 20 between clones	95% (CI 90–98%)
NPA at CPS ≥ 20 between clones	87% (CI 80–91%)
Kappa for three categories (CPS < 1, CPS ≥ 1, and CPS ≥ 20)	0.878 (CI 0.813–0.943)
OPA for three categories (CPS < 1, CPS ≥ 1, and CPS ≥ 20)	88% (CI 84–92%)

CI, confidence interval; CPS, combined positive score; NPA, negative percentage agreement; OPA, overall percentage agreement; PPA, positive percentage agreement.