. 2021 Nov 11;72(1):43–52. doi: 10.1111/pin.13185

Table 2.

Comparison of clinical findings between PC‐iMCD and IgG4‐RD

	Lymph node			Lung
	PC‐iMCD (n = 39)	IgG4‐RD (n = 22)	p‐value	PC‐iMCD (n = 19)	IgG4‐RD (n = 7)	p‐value
Age (mean ± SD)	53.9 ± 13.1	68.1 ± 9.3	<0.001	49.0 ± 11.5	65.9 ± 12.5	0.008
Sex (M/F)	25/14	7/15	‐	8/11	7/0	‐
Laboratory data (mean ± SD)
IgG (mg/dL)	4677 ± 1655^a	3393 ± 1309^b	0.013	4250 ± 1423^c	2770 ± 1192	0.018
IgG4 (mg/dL)	612 ± 670^a	836 ± 659^b	0.335	573 ± 448^c	1142 ± 590	0.013
serum IgG4/IgG (%)	12.3 ± 9.3^a	31.6 ± 10.7^b	<0.001	12.8 ± 8.9^c	40.7 ± 12.8	<0.001
IgA (mg/dL)	562 ± 251^a	152 ± 58^b	<0.001	599 ± 318^c	193 ± 75^d	<0.001
IgM (mg/dL)	240 ± 152^a	66 ± 41^b	<0.001	369 ± 89^c	ND	‐
IgE (IU/mL)	2929 ± 3760^a	878 ± 798^b	0.202	1149 ± 846^c	1812 ± 1800^d	1.000
CRP (mg/dL)	6.0 ± 4.6^a	0.1 ± 0.1^b	<0.001	4.6 ± 3.4^c	0.5 ± 0.6	<0.001

Note: Significant p‐values are in bold. Significance was calculated using the Mann–Whitney U‐test. Normal ranges: IgG, 870–1700 mg/dl; IgG4, 4.8–105 mg/dl; IgA, 110–410 mg/dl; IgM, 31–200 mg/dl (male), 52–270 mg/dl (female); IgE, 0–170 IU/ml; CRP, 0.00–0.30 mg/dl.

Abbreviations: CRP, C‐reactive protein; Ig, immunoglobulin; IgG4‐RD, immunoglobulin G4‐related disease; PC‐iMCD, plasma cell type idiopathic multicentric Castleman disease; ND, not done; SD, standard deviation.

^{^a}

IgG, IgG4, serum IgG4/IgG, IgA, IgM, IgE, and CRP were available for 33, 26, 18, 19, 19, 7, and 31 patients, respectively.

^{^b}

IgG, IgG4, serum IgG4/IgG, IgA, IgM, IgE, and CRP were available for 15, 17, 12, 12, 12, 5, and 18 patients, respectively.

^{^c}

IgG, IgG4, serum IgG4/IgG, IgA, IgM, IgE, and CRP were available for 19, 17, 17, 16, 2, 13, and 19 patients, respectively.

^{^d}

IgA and IgE levels were available for 6 and 5 patients, respectively.