Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 6;13:930227. doi: 10.3389/fendo.2022.930227

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Song, He, Indukuri, Huang, Stepanauskaite, Sinha, Haldosén, Zhao and Williams

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

ERα and ERβ regulate the transcriptome differently. (A) Heatmap illustrating E2-regulated gene expression profiles by ERα (left) and ERβ (right), as determined by RNA-seq. Red indicates higher expression, blue lower. The heatmap was generated using the web-based tool Morpheus (https://software.broadinstitute.org/morpheus/) and the gene expression data (log2fold change) were normalized by Z-score. (B) Overlap of all E2-regulated genes (top), and E2-upregulated genes specifically (bottom) by ERα or ERβ. (C) Enrichment analysis of biological functions related to the E2-upregulated genes (corresponding to the groups in B, lower panel) for ERα (147 genes, top), ERβ (293 genes, middle), and by both receptors (138 genes, lower graph) using DAVID.