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. 2022 Jul 6;13:930227. doi: 10.3389/fendo.2022.930227

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Copyright © 2022 Song, He, Indukuri, Huang, Stepanauskaite, Sinha, Haldosén, Zhao and Williams

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The ERs cistrome and transcriptome. (A) Venn diagram comparing ERα and ERβ binding sites. (B) Top-3 enriched motifs in ERα-specific, common core, and ERβ-specific cistrome. (C) Venn diagrams of ERα and ERβ transcriptome and cistrome data from MCF7 cells identify 109 genes regulated uniquely by ERβ through both chromatin-binding and transcriptional regulation, but only 30 genes that are unique for ERα. (D) Enrichment analysis of biological functions for the 109 uniquely ERβ-regulated genes. (E) Top-3 enriched motifs among ERβ-specifically regulated genes, and those regulated by both ERs. (F, G) Confirmation of ER binding and regulation of ANXA9 and TFAP2C with ChIP-qPCR and qPCR. Data is shown as means ± SD (n=3), and analyzed by two-way ANOVA followed by Bonferroni test. P < 0.05, **P < 0.01, ***P < 0.001, NS, Not significant.