Table 1.
GO biological processes analysis for E2-upregulated genes.
| By ERα | Genes | P value | Gene names |
|---|---|---|---|
| Cell proliferation | 5 | 0.01 | BCL2, MYC, POLR3G, FOXC1, MCM10 |
| Ovarian follicle development | 3 | 0.03 | BCL2, MYC, FOXC1 |
| Mesenchymal cell development | 2 | 0.04 | BCL2, FOXC1 |
| Cellular response to glucose starvation | 3 | 0.04 | BCL2, XBP1, SLC2A1 |
| Negative regulation of apoptotic process | 8 | <0.05 | BCL11B, BCL2, FCMR, GRK5, HCK, MYC, XBP1, ADORA1 |
| By ERβ | |||
| Negative regulation of meiotic nuclear division | 3 | 0.003 | FBXO5, LIF, RPS6KA2 |
| Negative regulation of cell proliferation | 14 | 0.004 | E2F7, JAK2, KISS1, LIF, WNT9A, AZGP1, CHD5, COL18A1, CDKN2D, EREG, RPS6KA2, SULT2B1, TPBG, ZNF503 |
| Extracellular matrix organization | 9 | 0.01 | ADAMTSL5, CD44, KAZALD1, CCDC80, COL18A1, FGG, FN1, LAMA3, LAMC2 |
| Intracellular signal transduction | 12 | 0.02 | JAK2, TNIK, DGKZ, DNMBP, HSPB1, MAP4K3, NRG3, PPP1R1C, RPS6KA2, SCG2, SGK1, TNS1 |
| Negative regulation of transcription involved in G1/S transition of mitotic cell cycle | 2 | 0.04 | E2F1, E2F7 |
| By both ERs | |||
| Cellular response to estradiol stimulus | 5 | 0.0001 | GPER1, ITGA2, NRIP1, SSTR2, ZNF703 |
| Synaptic transmission, glutamatergic | 4 | 0.0008 | CNIH2, GRIK3, GRIK4, SLC1A4 |
| Modulation of synaptic transmission | 4 | 0.007 | GPER1, GRIK3, GRIK4, SLC7A11 |
| Neuropeptide signaling pathway | 4 | 0.03 | GAL, NXPH3, NPY1R, SSTR2 |
| Inflammatory response | 7 | 0.04 | GPER1, GPR68, C5AR2, GAL, IL1RAP, LOXL3, SERPINA3 |