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. 2022 Jul 6;9:895797. doi: 10.3389/fcvm.2022.895797

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Copyright © 2022 Wei, Wu, Pan, Zhang, He, Xia, Xia, Lin and Shang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Herba Siegesbeckiae (HS) on Ischemia/Reperfusion (I/R)-elicited oxidative stress. (A–C) The plasma contents of ROS (A), RNS (B), and NO (C) in different groups (n = 9). (D) Representative ROS immunofluorescence photographs stained by DHE in Sham (d1), I/R (d2), and HS4 + I/R (d3) groups. Bar = 50 μm. (E,F) The contents of MDA (E) and 8-OHdG (F) in the left ventricle in various groups (n = 6). (G,H) The representative protein expression and quantitative analysis of MnSOD and Acy-MnSOD in left ventricle (n = 3). (I) The activity of MnSOD in the left ventricle in different groups (n = 6). *P < 0.05 vs. Sham group, ^#P < 0.05 vs. I/R group.