Table 2.
The factors associated with 3-year overall survival in AIDS-related lymphoma patients (n = 138).
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age > 60 | 1.440 (0.906–2.289) | 0.123 | 1.721 (1.014–2.921) | 0.044 |
| Male | 1.135 (0.640–2.016) | 0.664 | ||
| LDH > 250 | 2.315 (1.278–4.192) | 0.006 | 1.877 (0.806–4.372) | 0.145 |
| ECOG PS > 1 | 1.895 (1.232–2.914) | 0.004 | 1.429 (0.787–2.593) | 0.241 |
| Ann Arbor stage III/IV | 1.548 (1.008–2.377) | 0.046 | 1.660 (0.875–3.148) | 0.121 |
| Extranodal sites > 1 | 1.226 (0.763–1.970) | 0.400 | 2.252 (1.061–4.781) | 0.035 |
| Bulky mass ≥ 7 | 1.833 (1.192–2.817) | 0.006 | 1.736 (1.037–2.908) | 0.036 |
| B symptoms (present) | 2.024 (1.199–3.416) | 0.008 | 1.259 (0.621–2.554) | 0.523 |
| IPI | <0.001 | |||
| Low-intermediate | 3.067 (1.685–5.583) | |||
| High-intermediate | 3.009 (1.584–5.715) | |||
| High | 3.289 (1.719–6.294) | |||
| Prior history of HIV | 1.084 (0.656–1.792) | 0.753 | ||
| CD4 T cell < 300 | 3.021 (1.599–5.709) | 0.001 | 2.378 (1.236–4.573) | 0.009 |
| CD4/CD8 ratio < 0.41 | 2.180 (1.292–3.678) | 0.004 | 2.103 (1.156–3.827) | 0.015 |
| PLT ≥ 300 | 0.798 (0.512–1.244) | 0.318 | ||
| LMR ≥ 3.65 | 0.622 (0.403–0.962) | 0.033 | 0.666 (0.345–1.287) | 0.227 |
| PLR ≥ 250 | 1.810 (1.171–2.797) | 0.008 | 1.088 (0.628–1.885) | 0.763 |
| RDW ratio ≥ 1.03 | 1.540 (0.993–2.391) | 0.054 | ||
| Hb/RDW ≥ 8.5 | 0.532 (0.340–0.834) | 0.006 | 0.746 (0.456–1.221) | 0.244 |
| ESR ≥ 80 | 1.951 (1.173–3.242) | 0.010 | 1.154 (0.637–2.089) | 0.637 |
| ALB < 32 | 2.369 (1.529–3.669) | <0.001 | 2.341 (1.436–3.820) | 0.001 |
| BMI | 0.172 | |||
| Overweight | 1.260 (0.691–2.295) | |||
| Emaciation | 1.578 (0.819–3.039) | |||
| aaIPI | 0.002 | |||
| Low-intermediate | 2.321 (0.891–6.048) | |||
| High-intermediate | 3.593 (1.385–9.324) | |||
| High | 5.053 (1.925–13.264) | |||
| NCCN-IPI | 0.004 | |||
| Low-intermediate | 1.664 (0.698–3.965) | |||
| High-intermediate | 3.351 (1.403–8.004) | |||
| High | 3.252 (1.155–9.154) | |||
LDH, lactate dehydrogenase; ECOG PS, Eastern Cooperative Oncology Group performance status; IPI, International Prognostic Index; PLT, platelet; LMR, lymphocyte to monocyte ratio; PLR, platelet to lymphocyte ratio; RDW ratio, red cell distribution width ratio; Hb/RDW, hemoglobin to red cell distribution width ratio; ESR, erythrocyte sedimentation rate; ALB, albumin; BMI, body max index; aaIPI, age-adjusted IPI; NCCN-IPI, National Comprehensive Cancer Network IPI P-value < 0.05.