Table 3.
The factors associated with progression-free survival in patients with AIDS-related lymphoma (n = 138).
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age > 60 | 1.365 (0.859–2.169) | 0.188 | 1.554 (0.917–2.633) | 0.102 |
| Male | 1.126 (0.634–1.998) | 0.686 | ||
| LDH > 250 | 2.212 (1.222–4.005) | 0.009 | 1.804 (0.776–4.193) | 0.170 |
| ECOG PS > 1 | 1.870 (1.216–2.875) | 0.004 | 1.399 (0.771–2.536) | 0.269 |
| Ann Arbor stage III/IV | 1.519 (0.989–2.332) | 0.056 | 1.611 (0.842–3.083) | 0.149 |
| Extranodal sites > 1 | 1.230 (0.766–1.976) | 0.391 | 2.232 (1.046–4.764) | 0.038 |
| Bulky mass ≥ 7 | 1.777 (1.155–2.732) | 0.009 | 1.713 (1.027–2.857) | 0.039 |
| B symptoms (present) | 1.934 (1.145–3.266) | 0.014 | 1.193 (0.588–2.424) | 0.625 |
| IPI | 0.001 | |||
| Low-intermediate | 2.837 (1.558–5.164) | |||
| High-intermediate | 3.022 (1.592–5.734) | |||
| High | 3.068 (1.604–5.870) | |||
| Prior history of HIV | 1.113 (0.673–1.840) | 0.676 | ||
| CD4 T cell < 300 | 3.022 (1.599–5.711) | 0.001 | 2.328 (1.210–4.479) | 0.011 |
| CD4/CD8 ratio < 0.41 | 2.190 (1.298–3.694) | 0.003 | 1.853 (1.030–3.334) | 0.040 |
| PLT ≥ 300 | 0.759 (0.487–1.183) | 0.223 | ||
| LMR ≥ 3.65 | 0.613 (0.396–0.947) | 0.027 | 0.638 (0.331–1.231) | 0.180 |
| PLR ≥ 250 | 1.896 (1.227–2.929) | 0.004 | 1.232 (0.711–2.133) | 0.457 |
| RDW ratio ≥ 1.03 | 1.536 (0.990–2.383) | 0.056 | ||
| Hb/RDW ≥ 8.5 | 0.532 (0.339–0.830) | 0.006 | 0.708 (0.434–1.157) | 0.168 |
| ESR ≥ 80 | 1.931 (1.161–3.210) | 0.011 | 1.213 (0.675–2.180) | 0.520 |
| ALB < 32 | 2.295 (1.484–3.547) | <0.001 | 2.225 (1.362–3.636) | 0.001 |
| BMI | 0.186 | |||
| Overweight | 1.253 (0.688–2.284) | |||
| Emaciation | 1.556 (0.808–2.996) | |||
| aaIPI | 0.003 | |||
| Low-intermediate | 2.164 (0.830–5.638) | |||
| High-intermediate | 3.396 (1.309–8.811) | |||
| High | 4.628 (1.764–12.143) | |||
| NCCN-IPI | 0.005 | |||
| Low-intermediate | 1.558 (0.654–3.713) | |||
| High-intermediate | 3.172 (1.329–7.571) | |||
| High | 2.822 (1.003–7.943) | |||
LDH, lactate dehydrogenase; ECOG PS, Eastern Cooperative Oncology Group performance status; IPI, International Prognostic Index; PLT, platelet; LMR, lymphocyte to monocyte ratio; PLR, platelet to lymphocyte ratio; RDW ratio, red cell distribution width ratio; Hb/RDW, hemoglobin to red cell distribution width ratio; ESR, erythrocyte sedimentation rate; ALB, albumin; BMI, body max index; aaIPI, age-adjusted IPI; NCCN-IPI, National Comprehensive Cancer Network IPI. P-value < 0.05.