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Schematic representation of tanshinones inhibiting T3SS needle elongation. PscF, PscG, and PscE form a complex that facilitates proper translocation of PscF and subsequent needle assembly (Quinaud et al., 2005; Feng et al., 2019). The tanshinones can act as competitive inhibitors to interrupt the complex formation, resulting in disruption of T3SS needle biogenesis (Quinaud et al., 2005; Feng et al., 2019).
