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. 2022 Jul 20;12(7):e989. doi: 10.1002/ctm2.989

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© 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Exosomes derived from cancer‐associated fibroblasts (CAFs) induce tumour growth and chemoresistance, and activate PI3K/AKT pathway in a nude mouse non‐small‐cell lung cancer (NSCLC) model. HCC827 cells were processed with exosomes derived from normal tissue‐associated fibroblasts (NAFs) or CAFs were subcutaneously injected into nude mice, which were treated or untreated with DDP. (A) Subcutaneous tumours in each group were excised and displayed. (B) Tumour volume was measured at the end of 3, 7, 14, 21 and 28 days. (C) qPCR analysis of miR‐20a expression in tumours. (D) Western blotting analysis of PTEN, PI3K‐p85, PI3K‐p100, PI3K, pAKT and AKT. Outcomes are means ± standard deviation (SD) (*p < .05; **p < .01; ***p < .001)