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. 2022 Jul 20;12(7):e989. doi: 10.1002/ctm2.989

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© 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Overexpression of miR‐20a promotes cisplatin‐resistant in A549/DDP and H1299/DDP cells. (A and B) qRT‐PCR results showed that the expression levels of miR‐20a were increased or decreased in A549/DDP and H1299/DDP cells after miR‐20a mimics or inhibitor transfection. (C and D) Overexpression of miR‐20a led to a substantial increase in the DDP IC50 value, whereas suppression of miR‐20a expression by miR‐20a led to a substantial decrease in the DDP IC50 value in A549/DDP and H1299/DDP cells, and outcomes are means ± standard deviation (SD) (**p < .01; ***p < .001)