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Desired cascades for synthesizing 5‐aminoimidazole‐4‐carboxamide ribonucleotide mono‐, di‐ and tri‐phosphate (ZMP, ZDP, and ZTP). The adenine phosphoribosyltransferase (EcAPT) catalyzes the coupling of the base AICA to the ribose moiety (PRPP) to form ZMP. A combination of the EcAPT with different polyphosphate kinases shall then be used to create cascades for the biosynthesis of ZDP (AjPPK) and ZTP (MrPPK).
