TABLE 4.
Univariable and multivariable associations of age with early mortality a due to AML (excl. APL and ML‐DS) in children and AYAs (0‐39 years), the Netherlands, 1990‐2015
| Univariable | Adjusted 1 b | Adjusted 2 c | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable | Nearly death | OR | 95% CI | P‐value | OR | 95% CI | P‐value | OR | 95% CI | P‐value |
| Age | ||||||||||
| Children (0‐17 years) | 39 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | ||||||
| AYAs (18‐39 years) | 75 | 0.97 | (0.65‐1.45) | .89 | 0.95 | (0.63‐1.42) | .80 | 0.68 | (0.44‐1.04) | .07 |
| Age (years) | ||||||||||
| 0 | 13 | 6.47 | (2.65‐15.79) | <.001 | 7.23 | (2.93‐17.86) | <.001 | 6.74 | (2.67‐17.00) | <.001 |
| 1‐9 | 9 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | ||||||
| 10‐17 | 17 | 2.34 | (1.02‐5.34) | .04 | 2.40 | (1.05‐5.51) | .04 | 2.12 | (0.91‐4.93) | .08 |
| 18‐29 | 29 | 1.88 | (0.88‐4.03) | .10 | 1.86 | (0.86‐3.99) | .11 | 1.19 | (0.54‐2.63) | .66 |
| 30‐39 | 46 | 2.22 | (1.07‐4.59) | .03 | 2.26 | (1.09‐4.70) | .03 | 1.57 | (0.74‐3.34) | .24 |
Note: Statistically significant P values (P < .05) are displayed in bold.
Abbreviations: AML, acute myeloid leukemia; APL, acute promyelocytic leukemia; AYAs, adolescents and young adults; CI, confidence interval; ML‐DS, myeloid leukemia associated with Down syndrome; OR, odds ratio.
Early mortality was defined as death within 30 days of diagnosis.
Adjusted for sex (male, female) and period of diagnosis (1990‐1999, 2000‐2009, 2010‐2015).
Adjusted for sex (male, female), period of diagnosis (1990‐1999, 2000‐2009, 2010‐2015) and site of primary treatment (nonacademic hospital, academic hospital).