Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Catalyst screening for the Negishi coupling of 5‐bromoindole 1 with iodoalanine 8.
|
| ||
|---|---|---|
|
Entry |
Catalyst |
Conversion [%][a] |
|
1 |
Pd(amphos)2Cl2 |
>99 |
|
2 |
Pd2(dba)3/sPhos |
36 |
|
3 |
Pd2(dba)3/P(o‐tol)3 |
6 |
|
4 |
PdCl2 |
0 |
|
5 |
Pd/C |
0 |
|
6 |
Ni(dppe)Cl2 |
traces |
[a] conversion of 1 to 11 b determined by RP‐HPLC at 220 nm.
