Figure 1.

Schematic representation of the nhPHIP‐NMR method: substrates (sub) and p‐H₂ bind reversibly to an organometallic catalyst, allowing the signalling of the substrates by a pair of hydrides that can be detected in an NMR spectrum with enhanced sensitivity. The Ir‐IMes complex is formed after hydrogenation of the [Ir(IMes)(COD)Cl] pre‐catalyst in the presence of an excess of a co‐substrate (co‐sub), where IMes stands for 1,3‐bis(2,4,6‐trimethylphenyl)imidazole‐2‐ylidene and COD for cyclooctadiene.