FIGURE 9.

FBXW24 working model. This model showed the correlation between FBXW24, SYCP3 degraded, DSB repaired, and meiotic progression from pachytene to MII. In WT female germ cells, an average level of FBXW24 promotes SYCP3 degradation during pachytene, which subsequently promotes DSB repair. Therefore, germ cells can keep progressing till MII. In Fbxw24‐KO female germ cells, Fbxw24 knockout delayed SYCP3 degradation, subsequently, DSB cannot be repaired, pachytene progression is delayed; delayed Sycp3 degradation and unrepaired DSB remained until MII, which conduced to non‐separated homologous chromosomes and unrepaired DSB, ultimately resulted in MII oocyte death