TABLE 2.

Parameter estimates of the population pharmacokinetic plasma and saliva model

	Parameter	Estimate (shrinkage %)	SE	RSE (%)
Plasma kinetics	θ k a ‐ slow group (h−1)	1.106	0.14	12.8
	θ Prob. slow group	0.75	0.10	13.0
	θ V D central (L)	109.5	11.5	10.4
	θ clearance (L h−1)	2.98	0.16	5.5
	θ V D peripheral (L)	130.6	12.9	9.9
	θ Q (L h−1)	61.37	11.2	18.3
Saliva kinetics	θ F saliva (% 1000−1)	0.033	0.005	14.5
	θ K el saliva (h−1)	1.95	0.12	6.0
	θ RatioMAX	0.195	0.031	16.0
	θ RatioKM (μg/L)	2.581	0.74	28.5
IIV	ω 2 k a ‐ slow group	0.16 [2.24%]	0.065	40.8
	ω 2 Q	0.25 [0.33%]	0.12	45.7
	ω 2 F plasma	0.026 [3.98%]	0.008	28.9
	ω 2 F saliva	0.28 [5.30%]	0.12	42.7
	ω 2 K el saliva	0.056 [17.2%]	0.025	44.2
Residual error	σ 2 proportional plasma	0.0058 [15.9%]	0.0009	14.9
	σ 2 proportional saliva	0.057 [16.5%]	0.009	15.4

Note: ω ² and σ ² are the variances of interindividual variability and residual variability, respectively.

TVCL = θ clearance × (WGT/70)^0.75, TVVC = θ V _D centrasl × (WGT/70)¹, TVVP = θV _D peripheral × (WGT/70)¹, TVQ = θ Q × (WGT/70)^0.75, TVRatio = Ratio_MAX × C _PLASMA/(C _PLASMA + Ratio_KM).

Abbreviations: IIV, interindividual variability; RSE, relative standard error; SE. standard error.