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. 2021 Dec 3;61(3):e202114235. doi: 10.1002/anie.202114235

Figure 1.

Figure 1

a) Selected N‐heterocyclic spirocycles in FDA approved pharmaceuticals. b) Azabicyclo[1.1.0]butane (ABB) in the synthesis of azetidine‐containing spirocycles. c) This work: strain‐release‐driven intramolecular Friedel–Crafts spirocyclization.