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. 2021 Dec 3;61(3):e202114235. doi: 10.1002/anie.202114235

Scheme 5.

Scheme 5

Substrate scope for the electrophile‐induced rearomatization in the Friedel–Crafts spirocyclization reaction. All reactions were carried out using 2 j (0.20 mmol) in CHCl3 (2.0 mL). Isolated yields given. [a] 3.0 equiv of electrophile, heated to 50 °C for 16 h. [b] 15 % of C‐2 regioisomer detected by 1H NMR spectroscopy. [c] 40 h reaction time.