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. 2021 Dec 16;55(1):295–317. doi: 10.1111/ejn.15544

TABLE 1.

Overview table of studies investigating nociception following early life SSRI exposure

Reference Type of study Sex SSRI (/day) Time of exposure Test Results
G0–22 P1–3 P4–7 P8–14 P15–21
Thermal threshold
Butkevich and Mikhailenko (2018). Rat F FLX to dams G9–G20 Hot plate Hypersensitivity: decreased thermal threshold in control. No change in FLX injected adults.
10 mg/kg
Toffoli et al. (2014). Rat M FLX to dams G0–P21 Hot plate Hyposensitivity: increased thermal threshold.
5 mg/kg
Lee (2009). Rat M/F FLX P0–P6 Hot plate Hyposensitivity: increased thermal threshold.
10 mg/kg
Knaepen et al. (2013) Rat M/F FLX to dams G21–P21 Laser beam No effects.
10 mg/kg
Lisboa et al. (2007) Mouse M/F FLX to dams G0–P21 Hot plate No effects.
20–40 mg/kg
Vartazarmian et al. (2005) Guinea pigs M/F FLX to dams G1–P1 Hot plate Hypersensitivity: decreased thermal threshold in control. No change in FLX injected adults.
10 mg/kg
Mechanical threshold
Knaepen et al. (2013) Rat M/F FLX to dams G21–P21 vFh Decreased mechanical withdrawal thresholds. Postoperative mechanical sensitivity.
10 mg/kg
Oberlander et al. (2002) Clinical M/F FLX, PAR, BNZ, SET. Prenatal or postnatal Face reactivity Decreased facial sensitivity/reactivity at 2 days old.
Oberlander et al. (2005) Clinical M/F FLX, PAR, BNZ, SET. Prenatal or postnatal Face reactivity Decreased facial sensitivity/reactivity at 2 months old.
Morag et al. (2004) Clinical M PAR (20 mg/day) Prenatal Face reactivity No facial sensitivity before 13th days of life.

Note: Most preclinical studies investigated thermal threshold and only one researched mechanical threshold. Three clinical studies were encounter. Studies are display according to the following criteria: (1) animal model used (rats, mouse, other); (2) Time of SSRI exposure (prenatal administration, perinatal administration, P1 to P3, P4 to P7, P8 to P14, and P15 to P21, SERT‐KO). FLX: fluoxetine; PAR: paroxetine; BNZ: benzamidine; SER: sertraline; vFh: von Frey hair filaments; M: male; F: female; P: postnatal day; G: gestational day.