TABLE 1.
Reference | Type of study | Sex | SSRI (/day) | Time of exposure | Test | Results | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
G0–22 | P1–3 | P4–7 | P8–14 | P15–21 | |||||||
Thermal threshold | |||||||||||
Butkevich and Mikhailenko (2018). | Rat | F | FLX to dams | G9–G20 | Hot plate | Hypersensitivity: decreased thermal threshold in control. No change in FLX injected adults. | |||||
10 mg/kg | |||||||||||
Toffoli et al. (2014). | Rat | M | FLX to dams | G0–P21 | Hot plate | Hyposensitivity: increased thermal threshold. | |||||
5 mg/kg | |||||||||||
Lee (2009). | Rat | M/F | FLX | P0–P6 | Hot plate | Hyposensitivity: increased thermal threshold. | |||||
10 mg/kg | |||||||||||
Knaepen et al. (2013) | Rat | M/F | FLX to dams | G21–P21 | Laser beam | No effects. | |||||
10 mg/kg | |||||||||||
Lisboa et al. (2007) | Mouse | M/F | FLX to dams | G0–P21 | Hot plate | No effects. | |||||
20–40 mg/kg | |||||||||||
Vartazarmian et al. (2005) | Guinea pigs | M/F | FLX to dams | G1–P1 | Hot plate | Hypersensitivity: decreased thermal threshold in control. No change in FLX injected adults. | |||||
10 mg/kg | |||||||||||
Mechanical threshold | |||||||||||
Knaepen et al. (2013) | Rat | M/F | FLX to dams | G21–P21 | vFh | Decreased mechanical withdrawal thresholds. Postoperative mechanical sensitivity. | |||||
10 mg/kg | |||||||||||
Oberlander et al. (2002) | Clinical | M/F | FLX, PAR, BNZ, SET. | Prenatal or postnatal | Face reactivity | Decreased facial sensitivity/reactivity at 2 days old. | |||||
Oberlander et al. (2005) | Clinical | M/F | FLX, PAR, BNZ, SET. | Prenatal or postnatal | Face reactivity | Decreased facial sensitivity/reactivity at 2 months old. | |||||
Morag et al. (2004) | Clinical | M | PAR (20 mg/day) | Prenatal | Face reactivity | No facial sensitivity before 13th days of life. |
Note: Most preclinical studies investigated thermal threshold and only one researched mechanical threshold. Three clinical studies were encounter. Studies are display according to the following criteria: (1) animal model used (rats, mouse, other); (2) Time of SSRI exposure (prenatal administration, perinatal administration, P1 to P3, P4 to P7, P8 to P14, and P15 to P21, SERT‐KO). FLX: fluoxetine; PAR: paroxetine; BNZ: benzamidine; SER: sertraline; vFh: von Frey hair filaments; M: male; F: female; P: postnatal day; G: gestational day.