Table 1.

Uni‐ and multi‐variate regression to predict TRG 1–3 versus TRG 4, 5 in pre‐nCRT biopsies.

	Fisher's exact test			Univariate logistic regression				Multivariate logistic regression
	Mandard low	Mandard high	P value	OR	95% CI lower	95% CI upper	P value	OR	95% CI lower	95% CI upper	P value
	n = 48	n = 33
Age			0.498	0.967	0.919	1.019	0.209	1.048	0.984	1.116	0.149
<60	21 (65.6%)	11 (34.4%)
>60	27 (55.1%)	22 (44.9%)
T‐stage			0.489	0.982	0.370	2.604	0.971				0.88
1	0 (0.0%)	1 (100%)						5.5E+08	0	NA	1
2	8 (72.7%)	3 (27.3%)						0.372	0.018	7.638	0.521
3	38 (57.6%)	28 (42.4%)						0.67	0.046	9.83	0.77
4	2 (66.7%)	1 (33.3%)
N‐stage			0.980	0.945	0.525	1.700	0.850				0.573
0	11 (61.1%)	7 (38.9%)						0.381	0.043	3.393	0.387
1	33 (58.9%)	23 (41.1%)						0.333	0.043	2.566	0.291
3	4 (57.1%)	3 (42.9%)
CPS ≥ 1			0.010	0.157	0.033	0.745	0.020	5.184	0.927	28.995	0.061
No	34 (52.3%)	31 (44.7%)
Yes	14 (87.5%)	2 (12.5%)
CPS ≥ 10			0.142	0.000	0.000	NA	0.999
No	44 (57.1%)	33 (42.9%)
Yes	4 (100%)	0 (0%)
Total mean density tumor epithelium				1.002	1.000	1.003	0.025	0.998	0.995	1.002	0.318
Total mean density tumor stroma				1.002	1.000	1.004	0.044	0.999	0.995	1.004	0.798

P values in bold are statistically significant.

CPS, combined positive score; NA, not available.