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. 2021 Dec 10;49(1):309–323. doi: 10.1002/mp.15376

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© 2021 Siemens Medical Solutions USA, Inc. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Sample slice of positron emission tomography (PET) images from ordered subset expectation maximization (OSEM) using, from left to right, computed tomography (CT)–based, maximum likelihood estimation of attenuation and activity (MLAA) with lutetium oxyorthosilicate (LSO) transmission events (Tx) before injection (b.i), maximum likelihood estimation of activity and attenuation correction coefficients (MLACF) with LSO‐Tx b.i., MLAA with LSO‐Tx after injection (a.i.), MLACF with LSO‐Tx a.i. attenuation maps, and non‐attenuation‐corrected (NAC) PET data