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. 2022 Jun 28;12:833814. doi: 10.3389/fonc.2022.833814

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Copyright © 2022 Li, Gao, Wang, Gu, Li, Zhang, Hu, He, Wang, Wang, Yi, Fu, Zhang, Ge, Chen and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ophiopogonin B (OP-B) induced ferroptosis in vivo. (A) Bioluminescence imaging of the OP-B-administered groups with right lung parenchyma injection of luciferase-labeled A549 cells. (B) Transmission electron microscopy images of the model group and the OP-B-administered group (2.5 mg/kg) in nude mice. (C) Immunofluorescence staining of the expression of AURKA in the model group and OP-B-treated group in nude mice. (D) Immunofluorescence staining of the expression of GPX4 in the model group and OP-B-treated group in nude mice. Data bars and error bars indicate the mean ± SD. ***p < 0.001.