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. 2022 Jun 28;12:833814. doi: 10.3389/fonc.2022.833814

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Copyright © 2022 Li, Gao, Wang, Gu, Li, Zhang, Hu, He, Wang, Wang, Yi, Fu, Zhang, Ge, Chen and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Induction of ferroptosis by ophiopogonin B (OP-B) in non-small cell lung cancer (NSCLC) cells through the downregulation of AURKA expression. (A) The expression of AURKA was determined using Western blot. (B) Level of malondialdehyde (MDA). (C) Level of glutathione (GSH). (D) Concentration of intracellular iron. (E) Mitochondrial membrane potential (MMP) assay. Magnification, ×200. Scale bar, 50 μm. (F) Western blot of the levels of the ferroptosis-related proteins GPX4, xCT, PTGS2, and ACSL4. The Western blot experiments for all proteins were repeated three times, except that for ACSL4 (repeated twice). Data bars and error bars indicate the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001. ns, no significance.