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. 2022 Jun 28;12:833814. doi: 10.3389/fonc.2022.833814

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Copyright © 2022 Li, Gao, Wang, Gu, Li, Zhang, Hu, He, Wang, Wang, Yi, Fu, Zhang, Ge, Chen and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characteristics of the prognostic genes in the gene signature. (A, B, D, E) Distribution of risk scores (A) and the patient survival time and non-small cell lung cancer (NSCLC) status (B) in The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) (D, E). The black dotted line is the optimal cutoff value used to classify patients into the low-risk and high-risk groups. (C, F) Heat map of the ferroptosis-related gene expression profiles in the prognostic features of NSCLC in TCGA (C) and GEO (F). “High” represents the high-risk group and “low” the low-risk group in the heat map.