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. 2022 Jun 28;12:833814. doi: 10.3389/fonc.2022.833814

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Copyright © 2022 Li, Gao, Wang, Gu, Li, Zhang, Hu, He, Wang, Wang, Yi, Fu, Zhang, Ge, Chen and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of AURKA promoted ferroptosis in non-small cell lung cancer (NSCLC) cells. (A) Western blot analysis of the expression level of AURKA in A549 cells transfected with the short hairpin RNA plasmids sh-AURKA-1 and sh-AURKA-2. (B) Level of malondialdehyde (MDA) in A549 cells. (C) Level of glutathione (GSH) in A549 cells. (D) Concentration of intracellular iron. (E) Reactive oxygen species (ROS) determination assay. Magnification, ×200. Scale bar, 50 μm. (F) Mitochondrial membrane potential (MMP) assay. Magnification, ×200. Scale bar, 50 μm. (G) Western blot of the levels of the ferroptosis-related proteins GPX4, xCT, PTGS2, and ACSl4. The assay was repeated three times. Data bars and error bars indicate the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001. ns, no significance.