Table 1.
In vitro activities of α‐alkyl‐N‐aryl mercaptoacetamides and α‐benzyl‐N‐aryl mercaptoacetamides against LasB.[a]
|
Compound |
R |
R1 |
IC50 [μM] |
|---|---|---|---|
|
4 |
3,4‐di‐Cl |
H |
6.6±0.3 |
|
7 a |
3,4‐di‐Cl |
Benzyl |
2.7±0.4 |
|
7 b |
3,4‐di‐Cl |
Cyclohexylmethyl |
12±3 |
|
7 c |
3,4‐di‐Cl |
Cyclopropylmethyl |
6.3±1.2 |
|
7 d |
H |
Benzyl |
1.2±0.1 |
|
7 e |
2‐Me |
Benzyl |
2.4±1.0 |
|
7 f |
3‐Me |
Benzyl |
1.0±0.4 |
|
7 g |
4‐Me |
Benzyl |
0.48±0.04 |
[a] Means±standard deviations of at least two independent experiments.