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. 2021 Dec 14;70(8):1536–1553. doi: 10.1002/glia.24128

FIGURE 1.

FIGURE 1

Scheme of the entorhinal cortex‐hippocampal connections. The hippocampal formation is located in the temporal lobe of the brain and receives contextual information from the entorhinal cortex via its projections (the perforant path, PP) to the dentate gyrus (DG). The medial entorhinal cortex conveys spatial information about the context received from the perirhinal cortex, whereas the lateral entorhinal cortex conveys sensory information about the nature of the context (the object) received from the parahippocampal cortex. PP axons segregate into the lateral and medial PP innervating respectively the outer third (OML) and middle third (MML) of the dentate molecular layer. Granule cells (GC) send projections to CA3 pyramidal neurons, which in turn project to the CA1 area