Table 1.
Relative quantification of cells. a
| Cells | Sample | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| NS | PsO | PP | GPP | SPD | AGEP | HS | SS | PG | |
| Epidermis | |||||||||
| Keratinocytes | |||||||||
| IL‐17E | ++ | +++ | +++ | +++ | +++ | +++ | + | +++ | + |
| iNOS | ++ | +++ | +++ | +++ | +++ | +++ | + | +++ | + |
| arg1 | + | + | + | + | +++ | + | + | + | + |
| Neutrophils | |||||||||
| MPO/IL‐17Elow/iNOS | − | −/+ | ++ | + | +/++ | − | −/+ | −/+ | ++ |
| iMCs | |||||||||
| MPO/CD68/iNOS/arg1 | − | − | − | + | + | + | − | + | − |
| Pustules, Munro, b iMCs | |||||||||
| MPO/CD68/iNOS/arg1 | − | − | − | ++ | + | + | − | − | − |
| MPO/iNOS | − | + | ++ | + | ++ | + | − | − | − |
| Dermis | |||||||||
| Neutrophils | |||||||||
| MPO/IL‐17Elow | −/+ | + | +++ | ++ | ++ | ++ | ++ | ++ | +++ |
| N1 | |||||||||
| MPO/iNOS | −/+ | + | +++ | + | ++ | + | + | + | +++ |
| N2 | |||||||||
| MPO/arg1 | − | −/+ | − | + | + | + | ++ | ++ | −/+ |
| iMCs | |||||||||
| MPO/CD68/iNOS/arg1 | − | −/+ | − | + | + | + | ++ | ++ | −/+ |
| Macrophages | |||||||||
| CD68/IL‐17E | + | +++ | +++ | ++ | ++ | ++ | ++ | ++ | +++ |
| M1 | |||||||||
| CD68/iNOS | + | ++ | +++ | + | ++ | + | + | + | +++ |
| M2 | |||||||||
| CD68/arg1 | + | ++ | −/+ | ++ | + | ++ | ++ | ++ | −/+ |
AGEP, acute generalized exanthematous pustulosis; GPP, generalized pustular psoriasis; HS, hidradenitis suppurativa; iMCs, immature myeloid cells; M1, proinflammatory macrophages; M2, anti‐inflammatory macrophages; N1, inflammatory neutrophils; N2, unknown function in skin; NS, normal skin; PG, pyoderma gangrenosum; PP, paradoxical psoriasis, PsO, chronic plaque‐type psoriasis, SPD, subcorneal pustular dermatosis of Sneddon–Wilkinson; SS, Sweet syndrome.
a
Expression: − (absent), + (low expression), ++ (medium expression), +++ (high expression).
b
Munro microabscesses.