TABLE 1.
Patient population
| Patient characteristics | No AL | AL | 95% CI | Total | P | |
|---|---|---|---|---|---|---|
| Age | Median (IQR) | 67.0 (58.8–74.8) | 67.4 (58.3–74.1) | 67.1 (58.7–74.7) | 0.624 | |
| Sex | Female | 1966 (92.3) | 164 (7.7) | 6.6–8.9 | 2130 (100) | <0.001 |
| Male | 2879 (88.1) | 388 (11.9) | 10.8–13 | 3267 (100) | ||
| (Missing) | 1 (100.0) | 0 (0.0) | 1 (100) | |||
| BMI | Median (IQR) | 25.2 (22.9–27.8) | 25.6 (23.3–28.4) | 25.3 (23.0–27.8) | 0.054 | |
| CCI | 2 | 2103 (90.6) | 218 (9.4) | n.a. | 2321 (100) | 0.602 |
| 3 | 867 (89.8) | 99 (10.2) | 10.8–13 | 966 (100) | ||
| 4–5 | 515 (89.4) | 61 (10.6) | 8.4–12.3 | 576 (100) | ||
| 6+ | 140 (88.1) | 19 (11.9) | 8.2–13.4 | 159 (100) | ||
| (Missing) | 1221 (88.7) | 155 (11.3) | 1376 (100) | |||
| ASA score | I | 564 (91.0) | 56 (9.0) | 9.6–13.1 | 620 (100) | 0.279 |
| II | 1950 (89.0) | 242 (11.0) | 6.9–11.6 | 2192 (100) | ||
| III | 1068 (88.0) | 146 (12.0) | 9.8–12.4 | 1214 (100) | ||
| IV | 55 (90.2) | 6 (9.8) | 10.3–14 | 61 (100) | ||
| (Missing) | 1209 (92.2) | 102 (7.8) | 1311 (100) | |||
| Weight loss a | No | 2789 (91.0) | 276 (9.0) | 6.4–9.4 | 3065 (100) | 0.045 |
| Yes | 277 (87.4) | 40 (12.6) | 8–10.1 | 317 (100) | ||
| (Missing) | 1780 (88.3) | 236 (11.7) | 2016 (100) | |||
| Smoking habits | No | 2395 (90.5) | 250 (9.5) | 10.3–13.2 | 2645 (100) | 0.290 |
| Yes | 903 (89.3) | 108 (10.7) | 8.4–10.6 | 1011 (100) | ||
| (Missing) | 1548 (88.9) | 194 (11.1) | 1742 (100) | |||
| Alcohol habits | No | 3008 (90.3) | 324 (9.7) | 9.7–12.7 | 3332 (100) | 0.724 |
| Yes | 254 (89.4) | 30 (10.6) | 8.7–10.8 | 284 (100) | ||
| (Missing) | 1584 (88.9) | 198 (11.1) | 1782 (100) | |||
| Perioperative treatment | No | 1216 (90.7) | 124 (9.3) | 1340 (100) | 0.851 | |
| Short‐course RT | 113 (92.6) | 9 (7.4) | n.a. | 122 (100) | ||
| Long‐course RT | 146 (91.2) | 14 (8.8) | n.a. | 160 (100) | ||
| Short‐course RT + CT | 189 (89.2) | 23 (10.8) | 7.8–10.9 | 212 (100) | ||
| Long‐course RT + CT | 1394 (89.9) | 156 (10.1) | 3.4–13.5 | 1550 (100) | ||
| CT | 377 (91.1) | 37 (8.9) | 4.9–14.3 | 414 (100) | ||
| (Missing) | 1411 (88.2) | 189 (11.8) | 1600 (100) | |||
| Neoadjuvant treatment | No | 1216 (90.7) | 124 (9.3) | 8.6–11.7 | 1340 (100) | 0.680 |
| Yes | 2219 (90.3) | 239 (9.7) | 6.4–12.1 | 2458 (100) | ||
| (Missing) | 1411 (88.2) | 189 (11.8) | 1600 (100) | |||
Bold indicated significance value (P < 0.05).
Abbreviations: AL, anastomotic leak; ASA, American Society of Anesthesiologists; BMI, body mass index; CCI, Charlson Comorbidity Index; CT, chemotherapy; IQR, interquartile range; RT, radiation therapy.
a
Weight loss: reduction of more than 10% of body weight within the last 6 months.