TABLE 3.
Clinical staging and pathological data
| No AL | AL | 95% CI | Total | P | ||
|---|---|---|---|---|---|---|
| Tumour distance from the AV (cm) | Median (IQR) | 9.0 (6.0–12.0) | 8.0 (5.0–11.0) | 9.0 (6.0–12.0) | 0.042 | |
| Cancer location (anatomical subdivision) | Upper rectum | 1482 (91.5) | 137 (8.5) | 3.7–17.6 | 1619 (100) | 0.004 |
| Middle rectum | 2153 (89.1) | 263 (10.9) | 8.9–11.6 | 2416 (100) | ||
| Lower rectum | 984 (87.8) | 137 (12.2) | 13.8–22.1 | 1121 (100) | ||
| (Missing) | 227 (93.8) | 15 (6.2) | 242 (100) | |||
| cT | cT0–1–2 | 1146 (92.2) | 97 (7.8) | 1243 | 0.043 | |
| cT3–4 | 2161 (90.2) | 236 (9.8) | 2397 | |||
| (Missing) | 1539 (87.5) | 219 (12.5) | 1758 | |||
| cN | cN0 | 1880 (92.2) | 159 (7.8) | 2039 | 0.166 | |
| cN1 | 499 (89.9) | 56 (10.1) | 555 | |||
| cN2 | 154 (93.3) | 11 (6.7) | 165 | |||
| (Missing) | 2313 (87.6) | 326 (12.4) | 2639 | |||
| cM | cM0 | 3299 (91.1) | 321 (8.9) | 3620 | 0.750 | |
| cM1 | 136 (91.9) | 12 (8.1) | 148 | |||
| (y)pT stage | In situ | 85 (94.4) | 5 (5.6) | 9.7–12.2 | 90 (100) | <0.001 |
| 0 | 388 (91.5) | 36 (8.5) | 10.4–14.3 | 424 (100) | ||
| 1 | 560 (93.6) | 38 (6.4) | 3.5–10 | 598 (100) | ||
| 2 | 1190 (90.8) | 121 (9.2) | 6–11.6 | 1311 (100) | ||
| 3 | 2210 (88.5) | 286 (11.5) | 4.5–8.6 | 2496 (100) | ||
| 4 | 302 (85.6) | 51 (14.4) | 7.7–10.9 | 353 (100) | ||
| (Missing) | 111 (88.1) | 15 (11.9) | 126 (100) | |||
| (y)pN stage | 0 | 3100 (91.0) | 307 (9.0) | 11–18.6 | 3407 (100) | <0.001 |
| 1 | 1047 (88.4) | 138 (11.6) | 1.8–12.5 | 1185 (100) | ||
| 2 | 612 (86.2) | 98 (13.8) | 6.8–18.9 | 710 (100) | ||
| (Missing) | 87 (90.6) | 9 (9.4) | 96 (100) | |||
| pM stage | 0 | 4210 (89.9) | 475 (10.1) | 9.9–13.6 | 4685 (100) | 0.371 |
| 1 | 470 (88.5) | 61 (11.5) | 11.4–16.6 | 531 (100) | ||
| (Missing) | 166 (91.2) | 16 (8.8) | 182 (100) | |||
| R grade | 0 | 4279 (90.5) | 449 (9.5) | 9.3–11 | 4728 (100) | 0.708 |
| 1 | 82 (89.1) | 10 (10.9) | 8.9–14.5 | 92 (100) | ||
| 2 | 143 (88.8) | 18 (11.2) | 5.1–13.9 | 161 (100) | ||
| (Missing) | 342 (82.0) | 75 (18.0) | 417 (100) | |||
| Mandard TRG No. | Median (IQR) | 3.0 (2.0–4.0) | 3.0 (2.0–4.0) | 3.0 (2.0–4.0) | 0.379 | |
| (Missing) | 3355 (89.8) | 382 (10.2) | 3737 (100) | |||
Bold indicated significance value (P < 0.05).
Abbreviations: (y)pN, pathological N stage according to the 8th edition of the TNM classification after neoadjuvant treatment (Y) when administered; (y)pT, pathological T stage according to the 8th edition of the TNM classification after neoadjuvant treatment (Y) when administered; AL, anastomotic leak; AV, anal verge; IQR, interquartile range; pM, pathological M stage according to the 8th edition of the TNM classification; R grade, residual tumour classification (R0 corresponds to resection for cure or complete remission; R1 to microscopic residual tumour and R2 to macroscopic residual tumour).