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. 2021 Dec 19;51(1):52–62. doi: 10.1111/jop.13267

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© 2021 The Authors. Journal of Oral Pathology & Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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CAV1 is associated with poorer prognosis and ferroptosis in TCGA HNSCC dataset. A. Heatmap showed the expression of ferroptosis driver and suppressor genes in HNSCC. B. Venn diagram showed 3 genes both expressed in selective ferroptosis suppressor group and differential expressed genes in HNSCC from TCGA. C. The GSEA analysis showed the expression of upregulated genes mediated by ROS, on the basis of highly expression of CAV1. D. Heatmap showed the different expression of genes that were related to CAV1. E. The expression of CAV1 in HNSCC cancer and normal tissues. (p < 0.0001) F. The overall survival rate was significantly different between the high and low expression of CAV1 in HNSCC patients (p = 0.0015). Data originated from TCGA database. (ns, no significant difference, · p < 0.1, ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001, ^**** p < 0.0001)