Table 2.

Results of the Cox proportional hazards models for the association between the studied syndromes with all‐cause mortality and the combined endpoint

All‐cause mortality					Combined endpoint
Conditions (no. of patients)	Model A		Model B		Model A		Model B
	HR (95% CI)	p‐value	HR (95% CI)	p‐value	HR (95% CI)	p‐value	HR (95% CI)	p‐value
No comorbidities (398)	1 [Reference]
Isolated ID (430)	1.66 (1.12–2.46)	0.011	1.53 (1.03–2.28)	0.03	1.43 (1.10–1.86)	0.006	1.30 (1.05–1.70)	0.045
Isolated anaemia (76)	2.3 (1.28–4.12)	0.005	1.90 (1.06–3.41)	0.02	1.63 (1.06–2.51)	0.023	1.4 (0.91–2.15)	0.11
Isolated CKD (209)	2.53 (1.66–3.86)	<0.001	1.66 (1.08–2.55)	0.02	1.60 (1.18–2.16)	<0.002	1.18 (0.87–1.61)	0.27
IDA (231)	3.33 (2.24–4.94)	<0.001	2.58 (1.73–3.85)	<0.001	2.36 (1.79–3.12)	<0.001	1.71 (1.29–2.26)	<0.001
CRIDS (336)	3.08 (2.12–4.48)	<0.001	1.74 (1.18–2.58)	0.004	2.6 (2.06–3.4)	<0.001	1.67 (1.29–2.17)	<0.001
CRAS (106)	5.25 (3.39–8.12)	<0.001	2.62 (1.66–4.14)	<0.001	3.3 (2.39–4.56)	<0.001	1.87 (1.34–2.61)	<0.001
CRAIDS (365)	4.93 (3.46–7.03)	<0.001	2.42 (1.66–3.53)	<0.001	3.62 (2.84–4.6)	<0.001	1.94 (1.50–2.51)	<0.001

Model A = univariable analysis. Model B = adjusted for BIOSTAT‐CHF models, but without haemoglobin. ²³

CI, confidence interval; CKD, chronic kidney disease; CRAIDS, cardio‐renal anaemia iron deficiency syndrome; CRAS, cardio‐renal anaemia syndrome; CRIDS, cardio‐renal iron deficiency syndrome; HR, hazard ratio; ID, iron deficiency; IDA, iron deficiency anaemia.