FIGURE 6.

Amitriptyline reduces the need for colchicine gout treatment. Dissociated and aggregated clinical data of 107,172 elderly (>65 years) patients from Santiago de Compostela (Spain) healthcare area were mined for 5 years. (a) Fisher Contingency exact test (* P<0.05) comparing the number of elderly (>65 years) patients requiring or not colchicine and amitriptyline. (b) Spearman correlation test (* P<0.05) comparing the number of colchicine (dose: 0.5 mg most used; 0.66 mg exact mean) and amitriptyline (dose: 25 mg most used; 27.3 mg exact mean) drug boxes consumed by individual elderly (>65 years) patients. (c) Amitriptyline effects on TLR4 and IL‐1 receptor ® crosstalk signalling activation and inhibition including NLRP3/IL‐1β axis, NF‐κB and AP1 MyD88‐dependent pathways and in hOCs