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. 2021 Dec 5;75(4):898–911. doi: 10.1002/hep.32169

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© 2021 The Authors. Hepatology published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Histopathology of PVT at the hilar region of explanted livers. Representative examples of the thickened tunica intima of the portal vein. A crescent‐shaped lamellar fibrosis of the intima is observed (A; ×20). EVG staining highlights intimal thickening (B; arrows indicating the tunica media; ×20). In the thickened intima, some parts show spindle‐shaped cells arranged in a lamellar fashion (C; ×200), while others consist of hypocellular densely collagenized fibrosis (D,E; both ×200). It is only focally immunoreactive to fibrin/fibrinogen (F), VWF (G), and CD61 (H; all ×200) [Color figure can be viewed at wileyonlinelibrary.com]