TABLE 3.
Functions of the Candidate Antigens and Their Physiological Function and/or Reported Disease Associations
| Associated Protein | Function 27 | Reported Disease Associations |
|---|---|---|
| MX1 (interferon‐induced GTP‐binding protein MX1) |
Interacts with the ankyrinlike repeat domain of the TRPC channels. 28 Antiviral activity against RNA and DNA viruses. 29 , 30 , 31 |
Neuropathic pain in mice 32 Intervertebral disc degeneration and consequent back pain in humans 33 |
| DBNL (drebrin‐like protein) | Involved in receptor‐mediated endocytosis, reorganizing the cytoskeleton to produce cell projections and synapse formations. It is an effector of antigen‐receptor signaling pathways in leukocytes, and it regulates T‐cell activation by bridging T‐cell receptors and the actin cytoskeleton to gene activation and endocytic processes. 34 | Alzheimer disease |
| KRT8 (keratin type II cytoskeletal 8) | Contractile apparatus to dystrophin at the costameres of striated muscle. |
Neuropathic pain Chronic inflammatory demyelinating polyneuropathy |
| LIN28A (protein lin‐28 homolog A) | RNA‐binding protein, inhibits processing of pre–let‐7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency, and metabolism. |
Chronic neuropathic pain Primary tumors |
| METTL3 (N6‐adenosine‐methyltransferase catalytic subunit) |
Forms heterodimer with METTL14 that methylates adenosine residues of some RNAs and regulates processes such as circadian clock, differentiation of stem cells, cortical neurogenesis, response to DNA damage, differentiation of T cells, and primary mRNA processing. Involved in response to DNA damage. |
Inflammatory pain Neuropathic pain |
| NCOA5 (nuclear receptor coactivator 5) |
Has both coactivator and corepressor functions. Interactions with nuclear receptors. |
Lipoprotein disorders Psoriasis Behcet syndrome |
| PTPN1 (tyrosine‐protein phosphatase nonreceptor type 1) |
Tyrosine‐protein phosphatase that regulates endoplasmic reticulum unfolded protein response. May play important role in signal transduction cascades. May regulate signaling pathway, which modulates cell reorganization and cell–cell repulsion. |
Type 2 diabetes |
| ZNF276 (zinc finger protein 276) | May be involved in transcriptional regulation. | Nil |
| MIF (macrophage migration inhibitory factor) |
Proinflammatory cytokine. Mediates and regulates the function of macrophages in host defense, and counteracts the anti‐inflammatory activity of glucocorticoids. |
Inflammatory and neuropathic pain Severe sepsis and septic shock |
Extracted from the UniProt Consortium 27 unless otherwise specified.
TRPC = transient receptor potential canonical.