TABLE 1.
Summary of measures and instruments used in the present study
| Instrument/measure | Domain/aim | Time point a | |||
|---|---|---|---|---|---|
| TA | TD | T6 | T12 | ||
| Sociodemographic questionnaire | Key sociodemographic and clinical data | x | – | – | – |
| Body‐mass‐index (BMI) | Weight/weight gain | x | x | x | x |
| Eating disorder examination interview (EDE; Cooper & Fairburn, 1987) b | Eating disorder diagnosis and symptomatology | x | x | x | x |
| Eating disorder examination questionnaire (EDE‐Q; Hilbert et al., 2007) | Eating disorder symptomatology (self‐report) | x | x | x | x |
| Eating disorder inventory‐2 (EDI‐2; Garner, 1991) | Eating disorder symptomatology | x | x | x | x |
| MINI interview/MINI‐KID interview (Sheehan et al., 1998) | Psychiatric comorbidity | x | |||
| Beck depression inventory‐II short version (Beck et al., 2006) | Level of depression | x | x | x | x |
| State‐trait anxiety inventory (state part only) (Spielberger, 2010) | Level of anxiety | x | x | x | x |
| Yale‐brown obsessive compulsive scale (Y‐BOCS; Goodman et al., 1989) | Obsessive compulsive thoughts and behaviours (self‐report and expert rating) | x | x | x | x |
| Social responsiveness scale (SRS) (Bölte & Poustka, 2007) b | Autistic traits (parent report) | x | ‐ | x | x |
| Gastrointestinal complaints questionnaire (Cuntz & Hiller, 1998) | Gastrointestinal complaints | x | x | x | x |
| Iowa gambling task (IGT; Bechara et al., 1994) | Executive functioning (decision‐making processes) | x | ‐ | x | x |
| Probabilistic reversal learning task (PRLT; Cools et al., 2009) | Cognitive flexibility | x | ‐ | x | x |
| Food and non‐food related Go/No go task (Rosval et al., 2006) | Sustained attention and response control | x | ‐ | x | x |
| UPPS‐P impulsive behaviour scale (negative urgency‐scale only) (Whiteside & Lynam, 2001) | Level of emotion‐driven impulsiveness | x | ‐ | x | x |
| BIS/BAS questionnaire (Carver & White, 1994) | Sensitivity for reward and punishment | x | ‐ | x | x |
| Wechsler intelligence test (two subtests: Matrices and vocabulary) WISC‐V (Petermann, 2017) or WAIS‐IV (Petermann, 2012) | Intelligence | ‐ | ‐ | x | ‐ |
| Stool sample | Composition of the gut‐microbiome | x | x | x | x |
| Food protocol | Dietary intake during 48 h prior stool sampling | x | x | x | x |
| Actimetre/physical activity tracker | Amount of physical activity (steps, active hours) during 48 h prior stool sampling | x | x | x | x |
| Serum/plasma sample | Diverse blood parameters including Hormones, gut permeability parameters (serum zonulin), systemic inflammation markers (interleukin IL‐6), hunger and satiety markers (ghrelin, α‐MSH‐reactive IgG) | x | x | x | x |
| (Functional) magnet resonance imaging c | Analysis of the underlying mechanism of the gut‐brain interaction | x | ‐ | x | x |
a
Definition of assessment time points: TA baseline assessment at admission, TD discharge assessment (only in anorexia nervosa patients), T6 post‐intervention assessment (6 months after baseline), T12 12‐month follow‐up assessment.
b
Assessed in anorexia nervosa patients only (not in healthy controls).
c
Assessed in 30 anorexia nervosa patients and 60 healthy controls only.