Figure 4.

RNA-seq analyses reveal that adult T-cells impact neonatal inflammatory response and proliferative potential. (A) Enrichment score of hallmark gene sets found differentially expressed in neonatal hearts of T-cell-transferred recipients at 1 dpi (false discovery rate < 0.05). (B) Enrichment plots for transcripts related to ‘Positive regulation of CD4 positive alpha beta T-cell activation’, ‘Positive regulation of CD8 positive alpha beta T-cell activation’, ‘Hallmark inflammatory responses’, ‘Reactome collagen biosynthesis’, ‘Developing heart’, ‘G2/M checkpoint’, ‘Regulation of monocyte chemotaxis’, ‘Hallmark interferon-gamma response’ and ‘Hallmark tumour necrosis factor signalling via NFKB’. ES: enrichment score, q: false rate discovery. (C) Network illustrating biological processes and pathways upregulated (red) or downregulated (blue) in hearts from P1 T-cell-transferred mice, harvested 1 dpi.