Table 2. Incidence and severity of HFS and its correlation with WHO and NCI CTCAE 5.0 scores.

Severity	WHO	NCI/CTCAE 5.0	Number of patients	%
Mild	Grade I: Dysesthesia/paresthesia, tingling in hands and feet.	Grade I: Minimal skin changes or dermatitis (erythema, oedema and hyperkeratosis), no pain.	11	73.30
Moderate	Grade II: Discomfort when walking and/or holding objects, pain, erythema and oedema.	Grade II: Moderate skin changes (scaling, blisters, bleeding, cracking and erosion) with pain, relative limitation.	3	20
Severe	Grade III: Painful swelling and erythema in hands and feet and around the fingernails and toenails.	Grade III: Severe skin changes (scaling, blisters, bleeding, fissures, erosions and hyperkeratosis) with pain.	1	6.70
	Grade IV: Erosion, ulceration, blisters and severe pain.	_	0	0