Table 3. Prognostic factor for DFS, univariate and multivariate analyses.
| Characteristics | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | HR 95% | p-value | HR | HR 95% | p-value | |
| Age | ||||||
| <65 | 1 | |||||
| ≥65 | 1.04 | 0.64–1.68 | 0.881 | |||
| Sex | ||||||
| Women | 1 | |||||
| Men | 0.933 | 0.58–1.50 | 0.773 | |||
| NF_ratio | ||||||
| <5 | 1 | |||||
| ≥5 | 1.28 | 0.59–2.80 | 0.535 | |||
| Albumin (g/dL) | ||||||
| <3.5 | 1 | |||||
| ≥3.5 | 1.24 | 0.70–2.21 | 0.454 | |||
| Albumin/Globulin | ||||||
| <1.5 | 1 | |||||
| ≥1.5 | 1.09 | 0.60–2.00 | 0.775 | |||
| Lauren | ||||||
| Intestinal | 1 | 1 | ||||
| Diffuse | 1.83 | 1.09–3.10 | 0.023 | 1.59 | 0.87–2.89 | 0.129 |
| Mixed | 2.04 | 1.02–4.07 | 0.043 | 1.3 | 0.60–2.80 | 0.504 |
| Who | ||||||
| Non Poorly cohesive | 1 | |||||
| Poorly cohesive | 1.53 | 0.95–2.45 | 0.079 | |||
| Lymphovascular invasion | ||||||
| No | 1 | |||||
| Yes | 1.73 | 0.792–3.78 | 0.169 | |||
| Perineural invasion | ||||||
| No | 1 | 1 | ||||
| Yes | 1.75 | 1.01–3.03 | 0.046 | 1.11 | 0.59–2.07 | 0.752 |
| pT | ||||||
| pT1–pT3 | 1 | 1 | ||||
| pT4 | 2.32 | 1.42–3.79 | 0.001 | 1.43 | 0.82–2.48 | 0.208 |
| pN | ||||||
| pN0–pN1 | 1 | 1 | ||||
| pN2 | 1.57 | 0.753–3.26 | 0.230 | 0.98 | 0.36–2.65 | 0.970 |
| pN3 | 4.36 | 2.32–8.17 | <0.001 | 1.33 | 0.20–8.69 | 0.766 |
| Clinical stage | ||||||
| II | 1 | 1 | ||||
| IIIA | 3.64 | 1.48–8.93 | 0.005 | 5.01 | 1.64–15.26 | 0.005 |
| IIIB | 8.49 | 3.38–21.3 | <0.001 | 14.23 | 2.28–88.87 | 0.005 |
| IIIC | 9.75 | 3.92–24.2 | <0.001 | 12.33 | 1.81–83.92 | 0.010 |
| Lymph node ratio | ||||||
| 0–13 | 1 | |||||
| 13.1–40 | 1.77 | 0.987–3.18 | 0.055 | 0.51 | 0.18–1.45 | 0.206 |
| >40 | 5.73 | 3.2–10.2 | <0.001 | 1.23 | 0.36–4.25 | 0.740 |
| Treatment | ||||||
| Surgery | 1 | 1 | ||||
| Adjuvant chemotherapy | 0.603 | 0.376–0.968 | 0.036 | 0.28 | 0.17–0.47 | <0.001 |
Significant p-values (<0.05) are shown in bold