Table 2. Effect of demographic and histopathological parameters on LRFS, DFS and OS. (N = 104).
| Parameter | n (%) | LRFS* | DFS* | OS* |
|---|---|---|---|---|
| Gender | ||||
| Male | 81 (77.9) | 0.221 | 0.335 | 0.107 |
| Female | 23 (22.1) | |||
| Masticator space involvement on CECT scan | ||||
| Present | 101 (97.1) | 0.323 | 0.374 | 0.384 |
| Absent | 3 (2.9) | |||
| Histopathological parameters | ||||
| Differentiation | ||||
| Well differentiated | 8 (7.8) | 0.018 | 0.029 | 0.012 |
| Moderately differentiated | 74 (74.6) | |||
| Poorly differentiated | 20 (19.6) | |||
| Margin status | ||||
| Free (>5 mm) | 79 (76) | <0.001 | <0.001 | 0.002 |
| Close (1–4.9 mm) | 23 (22.1) | |||
| Involved (<1 mm) | 2 (1.9) | |||
| LVI | ||||
| Absent | 62 (59.7) | 0.044 | 0.010 | 0.314 |
| Present | 42 (40.3) | |||
| PNI | ||||
| Absent | 47 (45.2) | <0.001 | <0.001 | 0.005 |
| Present | 57 (54.8) | |||
| Bone involvement | ||||
| Absent | 48 (46.1) | 0.328 | 0.295 | 0.048 |
| Superficial erosion | 9 (8.7) | |||
| Cortical erosion | 47 (45.2) | |||
| Masticator space involvement in final histopathology | ||||
| Absent | 68 (65.4) | 0.047 | 0.008 | 0.270 |
| Present | 36 (34.6) | |||
| ENE | ||||
| Absent | 92 (88.5) | 0.616 | 0.848 | 0.569 |
| Present | 12 (11.6) | |||
| pT stage | ||||
| pT1 | 7 (6.7) | 0.225 | 0.069 | 0.286 |
| pT2 | 21 (20.1) | |||
| pT3 | 7 (6.7) | |||
| pT4a | 33 (31.7) | |||
| pT4b | 36 (34.6) | |||
| pN stage | ||||
| pN0 | 47 (45.2) | <0.001 | <0.001 | 0.007 |
| pN1 | 13 (12.5) | |||
| pN2a | 0 | |||
| pN2b | 38 (36.5) | |||
| pN2c | 5 (4.9) | |||
| pN3 | 1 (1) | |||
| Adjuvant treatment | ||||
| Follow up | 22 (21.1) | 0.601 | 0.625 | 0.605 |
| Adjuvant RT | 62 (59.7) | |||
| Adjuvant CTRT | 20 (19.2) | |||
| Continuous variables | ||||
| Madian (range) | LRFS# | DFS# | OS# | |
| Age (years) | 52.5 (27–81) | 0.840 | 0.941 | 0.873 |
| T size (in cm) | 3.5 (0.5–9.5) | 0.049 | 0.100 | 0.015 |
| Depth of invasion (in cm) | 1.6 (0.1–7.2) | 0.012 | 0.004 | 0.001 |
*
Unadjusted ‘p’ value on Log rank test.
#
Unadjusted ‘p’ value on cox logistic regression.