Table 3. Adjusted HR and their significance.

Factor	LRFS		DFS		OS
	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
Differentiation
Well differentiated	1	---	1	---	1	---
Moderately differentiated	0.890 (0.095–8.337)	0.919	0.902 (0.099–8.256)	0.928	0.973 (0.092–10.334)	0.982
Poorly differentiated	2.692 (0.260–27.851)	0.406	2.304 (0.222–23.858)	0.484	3.982 (0.330–48.039)	0.277
Margin status
Free (>5 mm)	1	---	1	---	1	---
Close (1–4.9 mm)	2.018 (0.850–4.787)	0.111	1.739 (0.762–3.970)	0.189	2.262 (0.933–5.483)	0.071
Involved (<1 mm)	28.766 (2.625–315.271)	0.006	24.859 (2.350–262.881)	0.008	14.139 (1.434–139.362)	0.023
LVI	0.603 (0.231–1.567)	0.299	0.988 (0.418–2.332)	0.978	---	---
PNI	3.001 (1.135–7.938)	0.027	2.320 (0.945–5.697)	0.066	1.828 (0.721–4.633)	0.204
Bone invasion
No bone erosion	—	—	—	—	1	—
Superficial erosion	—	—	—	—	1.055 (0.285–3.901)	0.936
Cortical invasion	—	—	—	—	0.759 (0.306–1.882)	0.552
Masticator space invasion on histopathology	0.538 (0.226–1.280)	0.161	0.730 (0.327–1.629)	0.443	—	—
pN stage
pN0	1	—	1	—	1	—
pN1	1.661 (0.390–7.083)	0.492	1.306 (0.302–5.641)	0.721	0.581 (0.099–3.417)	0.548
pN2b	4.680 (1.721–12.725)	0.027	4.018 (1.543–10.464)	0.004	3.166 (1.152–8.699)	0.025
pN2c	2.675 (0.463–15.452)	0.272	2.381 (0.411–13.772)	0.333	2.479 (0.472–13.030)	0.284
pN3	0.762 (0.031–18.957)	0.869	0.870 (0.036–21.204)	0.932	2.984 (0.162–55.106)	0.462
T size (in cm)	1.292 (0.988–1.691)	0.061	—	—	1.139 (0.887–1.462)	0.308
Depth of invasion (in cm)	1.101 (0.791–1.432)	0.567	1.312 (1.022–1.685)	0.033	1.192 (0.841–1.690)	0.324