Table 4.

Summary statistics of the major pharmacokinetic parameters of bendamustine in patients analyzed for pharmacokinetics

Group (dose)	Cmax (ng/mL)	tmax (h)	AUC0-last (ng·h/mL)	AUC0-inf (ng·h/mL)	t1/2 (h)
Group 1 (90 mg/m2)
N	6	6	6	6	6
Mean	9809	0.18	4707	4708	0.43
SD	3418	0.03	1732	1732	0.11
%CV	34.8	18.8	36.8	36.8	26.0
Group 2 (120 mg/m2)
N	6	6	6	6	6
Mean	16256	0.18	8242	8244	0.50
SD	4434	0.06	2794	2796	0.07
%CV	27.3	34.7	33.9	33.9	14.5

C_max maximum concentration, t_max time of maximum observed concentration, AUC_0-last area under the concentration–time curve from the time of dosing to the time of the last measurable (positive) concentration, AUC_0-inf area under the concentration–time curve from the time of dosing extrapolated to infinity, t_1/2 elimination half-life, N number of patients, SD standard deviation, CV coefficient of variation