Table 2.

Health outcomes experienced over 35 years per patient in the base case (discounted)

	PSMA PET/CT	Conventional imaging (CT+WBBS)	Conventional imaging (CT alone)	Difference
				PSMA PET/CT vs CT+WBBS	PSMA PET/CT vs CT alone
True-positive cases detected (metastatic disease and test positive)	0.034	0.023	0.025	0.011	0.009
False-negative cases detected (metastatic disease but test negative)	0.026	0.037	0.035	− 0.011	− 0.009
True-negative cases detected (locoregional and test negative)	0.903	0.856	0.771	0.047	0.132
False-positive cases detected (locoregional but test positive)	0.038	0.085	0.169	− 0.047	− 0.132
Total cases	1.000	1.000	1.000	0.000	0.000
LYs experienced by patients with true-positive result	0.118	0.079	0.087	0.039	0.031
LYs experienced by patients with false-negative result	0.095	0.138	0.129	− 0.042	− 0.033
LYs experienced by patients with true-negative result	10.376	9.836	8.863	0.540	1.513
LYs experienced by patients with false-positive result	0.429	0.966	1.932	− 0.537	− 1.503
Total LYs gained over the 35 years	11.019	11.018	11.011	0.001	0.008
QALYs experienced by patients with true-positive result	0.075	0.050	0.055	0.025	0.020
QALYs experienced by patients with false-negative result	0.057	0.082	0.076	− 0.025	− 0.020
QALYs experienced by patients with true-negative result	7.903	7.492	6.751	0.412	1.153
QALYs experienced by patients with false-positive result	0.317	0.712	1.425	− 0.396	− 1.108
Total QALYs gained over the 35 years	8.352	8.336	8.307	0.016	0.044

CT computed tomography, LYs life-years, PET positron emission tomography, PSMA prostate-specific membrane antigen, QALYs quality-adjusted life-years, WBBS whole body bone scan