Table 3.
Costs experienced over 35 years per patient in the base case (discounted) [$A]
| Costs per patient over 35 years ($A) | PSMA PET/CT | Conventional imaging (CT+WBBS) | Conventional imaging (CT alone) | Difference | |
|---|---|---|---|---|---|
| PSMA PET/CT vs CT+WBBS | PSMA PET/CT vs CT alone | ||||
| No active treatment | $31 | $20 | $22 | $10 | $8 |
| Surgery | $207 | $138 | $151 | $69 | $56 |
| Radiotherapy | $334 | $222 | $243 | $112 | $91 |
| Radiotherapy + surgery | $0 | $0 | $0 | $0 | $0 |
| Radiotherapy + ADT | $957 | $636 | $694 | $321 | $263 |
| Chemotherapy | $578 | $384 | $419 | $194 | $158 |
| True-positive result (metastatic disease and test positive) | $2107 | $1400 | $1530 | $707 | $577 |
| No active treatment + no change in management | $42 | $60 | $55 | − 18 | − $14 |
| No active treatment + delayed ADT | $90 | $129 | $119 | − 39 | − 29 |
| No active treatment + delayed chemotherapy | $58 | $83 | $77 | − $25 | − 19 |
| Surgery + no change in management | $270 | $388 | $360 | − $118 | − $90 |
| Surgery + delayed ADT | $586 | $842 | $781 | − $257 | − $196 |
| Surgery + delayed chemotherapy | $365 | $524 | $487 | − $160 | − 122 |
| Radiotherapy + no change in management | $113 | $162 | $150 | − $49 | − $37 |
| Radiotherapy + delayed ADT | $242 | $347 | $322 | − $106 | − $80 |
| Radiotherapy + delayed chemotherapy | $152 | $219 | $203 | − $67 | − $51 |
| Radiotherapy + surgery + no change in management | $0 | $0 | $0 | $0 | $0 |
| Radiotherapy + surgery + delayed ADT | $0 | $0 | $0 | $0 | $0 |
| Radiotherapy + surgery + delayed chemotherapy | $0 | $0 | $0 | $0 | $0 |
| Radiotherapy +ADT | $66 | $95 | $88 | − $29 | − $22 |
| False-negative result (metastatic disease but test negative) | $1982 | $2850 | $2642 | − $868 | − $660 |
| No active treatment | $1917 | $1795 | $1549 | $123 | $368 |
| Surgery | $19,679 | $18,550 | $16,407 | $1129 | $3272 |
| Radiotherapy | $7582 | $7138 | $6287 | $444 | $1294 |
| Radiotherapy + surgery | $0 | $0 | $0 | $0 | $0 |
| Radiotherapy + ADT | $1097 | $1034 | $913 | $63 | $185 |
| True-negative result (locoregional and test negative) | $30,275 | $28,517 | $25,156 | $1758 | $5119 |
| No active treatment | $10 | $23 | $44 | − $13 | − $33 |
| Surgery | $110 | $246 | $482 | − $136 | − $373 |
| Radiotherapy | $163 | $364 | $711 | − $201 | − $548 |
| Radiotherapy + surgery | $0 | $0 | $0 | $0 | $0 |
| Radiotherapy + ADT | $473 | $1056 | $2055 | − $583 | − $1581 |
| Chemotherapy | $266 | $594 | $1155 | − $328 | − $889 |
| False-positive result (locoregional but test positive) | $1023 | $2283 | $4447 | − $1260 | − $3425 |
| Total cost per patient | $35,387 | $35,050 | $33,775 | $337 | $1612 |
A$ Australian Dollars, ADT androgen deprivation therapy, CT computed tomography, PET positron emission tomography, PSMA prostate-specific membrane antigen, WBBS whole body bone scan