Table 4.
Deterministic and probabilistic incremental cost-effectiveness ratios (ICERs) in the base case
| PSMA PET/CT | CT+WBBS | CT alone | Difference | ||
|---|---|---|---|---|---|
| PSMA PET/CT vs CT+WBBS | PSMA PET/CT vs CT alone | ||||
| Base-case results (deterministic) | |||||
| Total QALYs gained per patient | 8.352 | 8.336 | 8.307 | 0.016 | 0.044 |
| Total costs per patient (A$) | $35,387 | $35,050 | $33,775 | $337 | $1612 |
| ICER (A$ per QALY gained) | – | – | $21,147 | $36,231 | |
| Base-case results (probabilistic) | |||||
| Total QALYs gained per patient (95% CI) | 8.361 (7.891, 8.779) | 8.345 (7.868, 8.764) | 8.316 (7.836, 8.739) | 0.016 (− 0.002, 0.040) | 0.044 (0.029, 0.062) |
| Total costs per patient [A$] (95% CI) | $35,350 ($27,043, $48,545) | $35,008 ($26,668, $48,123) | $33,733 ($25,404, $46,890) | $342 (− $40, $918) | $1617 ($874, $2228) |
| ICER [A$ per QALY gained] (95% CI)a | – | – | – | $33,836 (− $14,280, $71,865) | $37,649 ($18,629, $59,745) |
A$ Australian Dollars, CI confidence interval, CT computed tomography, PET positron emission tomography, PSMA prostate-specific membrane antigen, QALYs quality-adjusted life-years, WBBS whole body bone scan
aThe difference in deterministic and probabilistic ICERs is because as the incremental effect approaches zero the ICER moves towards infinity, which biases the average probabilistic ICER upwards